MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

Cancer is a hyper-proliferative disease. Whether the proliferative state originates from the cell-of-origin or emerges later remains difficult to resolve. By tracking de novo transformation from normal hematopoietic progenitors expressing an acute myeloid leukemia (AML) oncogene MLL-AF9, we reveal t...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Chen, Xinyue, Burkhardt, Daniel B., Hartman, Amaleah A., Hu, Xiao, Eastman, Anna E., Sun, Chao, Wang, Xujun, Zhong, Mei, Krishnaswamy, Smita, Guo, Shangqin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920141/
https://ncbi.nlm.nih.gov/pubmed/31852898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13666-5
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