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Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
The drug-like molecule PF-06446846 (PF846) binds the human ribosome and selectively blocks the translation of a small number of proteins by an unknown mechanism. In structures of PF846-stalled human ribosome nascent chain complexes, PF846 binds in the ribosome exit tunnel in a eukaryotic-specific po...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6919564/ https://ncbi.nlm.nih.gov/pubmed/31160784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0236-8 |
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