A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries

Mouse models of gastroesophageal junction (GEJ) cancer strive to recapitulate the intratumoral heterogeneity and cellular crosstalk within patient tumors to improve clinical translation. GEJ cancers remain a therapeutic challenge due to the lack of a reliable mouse model for preclinical drug testing...

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Publicado en:Dis Model Mech
Autores principales: Veeranki, Omkara Lakshmi, Tong, Zhimin, Mejia, Alicia, Verma, Anuj, Katkhuda, Riham, Bassett, Roland, Kim, Tae-Beom, Wang, Jing, Lang, Wenhua, Mino, Barbara, Solis, Luisa, Kingsley, Charles, Norton, William, Tailor, Ramesh, Wu, Ji Yuan, Krishnan, Sunil, Lin, Steven H., Blum, Mariela, Hofstetter, Wayne, Ajani, Jaffer, Kopetz, Scott, Maru, Dipen
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2019
Materias:
Resource Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918774/
https://ncbi.nlm.nih.gov/pubmed/31732509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.041004
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