Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice

BACKGROUND: Alzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline. Current therapeutic approaches have primarily aimed to reduce patholog...

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Vydáno v:Alzheimers Res Ther
Hlavní autoři: Davtyan, Hayk, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Antonyan, Tatevik, Coburn, Morgan A., Zagorski, Karen, Chailyan, Gor, Petrushina, Irina, Svystun, Olga, Danhash, Emma, Petrovsky, Nikolai, Cribbs, David H., Agadjanyan, Michael G., Blurton-Jones, Mathew, Ghochikyan, Anahit
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918571/
https://ncbi.nlm.nih.gov/pubmed/31847886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0556-2
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