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Gas-Phase Sequencing of Cyclotides: Introduction of Selective Ring Opening at Dehydroalanine via Ion/Ion Reaction

The gas-phase linearization of cyclotides via site-selective ring opening at dehydroalanine residues and its application to cyclotide sequencing is presented. This strategy relies on the ability to incorporate dehydroalanine into macrocyclic peptide ions, which is easily accomplished through an ion/...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Foreman, David J., Parsley, Nicole C., Lawler, John T., Aryal, Uma K., Hicks, Leslie M., McLuckey, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917824/
https://ncbi.nlm.nih.gov/pubmed/31746593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b03671
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