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Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9

Herpes simplex virus (HSV) establishes lifelong latent infection and can cause serious human disease, but current antiviral therapies target lytic but not latent infection. We screened for sgRNAs that cleave HSV-1 DNA sequences efficiently in vitro and used these sgRNAs to observe the first editing...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Oh, Hyung Suk, Neuhausser, Werner M, Eggan, Pierce, Angelova, Magdalena, Kirchner, Rory, Eggan, Kevin C, Knipe, David M
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917492/
https://ncbi.nlm.nih.gov/pubmed/31789594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51662
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