Children with Narcolepsy type 1 have increased T‐cell responses to orexins

Narcolepsy type 1 (NT1) is caused by severe loss of the orexin neurons, and is highly associated with HLA DQB1*06:02. Using intracellular cytokine staining, we observed a higher frequency of IFN‐γ‐ and TNF‐α‐producing CD4(+) and CD8(+) T‐cells in response to orexins in 27 children with NT1 compared...

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Библиографические подробности
Опубликовано в: :Ann Clin Transl Neurol
Главные авторы: Cogswell, Andrew C., Maski, Kiran, Scammell, Thomas E., Tucker, Dominique, Orban, Zachary S., Koralnik, Igor J.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
Предметы:
Brief Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917326/
https://ncbi.nlm.nih.gov/pubmed/31730293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.50908
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