Reproducibility of cognitive endpoints in clinical trials: lessons from neurofibromatosis type 1

OBJECTIVE: Rapid developments in understanding the molecular mechanisms underlying cognitive deficits in neurodevelopmental disorders have increased expectations for targeted, mechanism‐based treatments. However, translation from preclinical models to human clinical trials has proven challenging. Po...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Payne, Jonathan M., Hearps, Stephen J. C., Walsh, Karin S., Paltin, Iris, Barton, Belinda, Ullrich, Nicole J., Haebich, Kristina M., Coghill, David, Gioia, Gerard A., Cantor, Alan, Cutter, Gary, Tonsgard, James H., Viskochil, David, Rey‐Casserly, Celiane, Schorry, Elizabeth K., Ackerson, Joseph D., Klesse, Laura, Fisher, Michael J., Gutmann, David H., Rosser, Tena, Packer, Roger J., Korf, Bruce, Acosta, Maria T., North, Kathryn N.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917317/
https://ncbi.nlm.nih.gov/pubmed/31797581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.50952
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