NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma

BACKGROUND: Our previous study has demonstrated that NAD(P)H: quinone oxidoreductase 1 (NQO1) is significantly upregulated in human liver cancer where it potentiates the apoptosis evasion of liver cancer cell. However, the underlying mechanisms of the oncogenic function of NQO1 in HCC have not been...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Zhou, Hong-Zhong, Zeng, Han-Qing, Yuan, Ding, Ren, Ji-Hua, Cheng, Sheng-Tao, Yu, Hai-Bo, Ren, Fang, Wang, Qing, Qin, Yi-Ping, Huang, Ai-Long, Chen, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915971/
https://ncbi.nlm.nih.gov/pubmed/31842909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0491-7
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