Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

Epigenetic alternations concern heritable yet reversible changes in histone or DNA modifications that regulate gene activity beyond the underlying sequence. Epigenetic dysregulation is often linked to human disease, notably cancer. With the development of various drugs targeting epigenetic regulator...

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Bibliographic Details
Published in:Signal Transduct Target Ther
Main Authors: Cheng, Yuan, He, Cai, Wang, Manni, Ma, Xuelei, Mo, Fei, Yang, Shengyong, Han, Junhong, Wei, Xiawei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915746/
https://ncbi.nlm.nih.gov/pubmed/31871779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0095-0
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