Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution Studies

Brigatinib and brigatinib-analog are potent and selective ALK inhibitors with the similar structure. A simple and sensitive high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of brigatinib and brigatinib-analog in rat plasma and brai...

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Detalhes bibliográficos
Publicado no:Int J Anal Chem
Main Authors: Li, Bo, Lu, Min, Jin, Lei, Zheng, Maoen, Sun, Peilu, Lei, Shanshan, Xiong, Shan, Chen, Suhong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915135/
https://ncbi.nlm.nih.gov/pubmed/31885594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/9028309
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