PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation has been identified as an HCC pro-metastatic activator associated with poor patient prognosis, but with a lack of targeting strategy. Here, we report that PSPC1,...

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Udgivet i:Nat Commun
Main Authors: Lang, Yaw-Dong, Chen, Hsin-Yi, Ho, Chun-Ming, Shih, Jou-Ho, Hsu, En-Chi, Shen, Roger, Lee, Yu-Ching, Chen, Jyun-Wei, Wu, Cheng-Yen, Yeh, Hsi-Wen, Chen, Ruey-Hwa, Jou, Yuh-Shan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6914800/
https://ncbi.nlm.nih.gov/pubmed/31844057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13665-6
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