GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models

Glucocerebrosidase (GBA) mutations are the most important genetic risk factor for the development of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase). Loss-of-GCase activity in cellular models has implicated lysosomal and mitochondrial dysfunction in PD disease pat...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Morén, Constanza, Juárez-Flores, Diana Luz, Chau, Kai-Yin, Gegg, Matthew, Garrabou, Glòria, González-Casacuberta, Ingrid, Guitart-Mampel, Mariona, Tolosa, Eduardo, Martí, María José, Cardellach, Francesc, Schapira, Anthony Henry Vernon
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6914435/
https://ncbi.nlm.nih.gov/pubmed/31751314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102460
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados