Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2(G2019S)-Parkinson’s disease

BACKGROUND: Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed to study the role of mitochondria and autoph...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Juárez-Flores, Diana Luz, González-Casacuberta, Ingrid, Ezquerra, Mario, Bañó, María, Carmona-Pontaque, Francesc, Catalán-García, Marc, Guitart-Mampel, Mariona, Rivero, Juan José, Tobias, Ester, Milisenda, Jose Cesar, Tolosa, Eduard, Marti, Maria Jose, Fernández-Santiago, Ruben, Cardellach, Francesc, Morén, Constanza, Garrabou, Glòria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994110/
https://ncbi.nlm.nih.gov/pubmed/29884186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1526-3
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