Intradermal HIV-1 DNA Immunization Using Needle-Free Zetajet Injection Followed by HIV-Modified Vaccinia Virus Ankara Vaccination Is Safe and Immunogenic in Mozambican Young Adults: A Phase I Randomized Controlled Trial

We assessed the safety and immunogenicity of HIV-DNA priming using Zetajet™, a needle-free device intradermally followed by intramuscular HIV-MVA boosts, in 24 healthy Mozambicans. Volunteers were randomized to receive three immunizations of 600 μg (n = 10; 2 × 0.1 ml) or 1,200 μg (n = 10; 2 × 0.2 m...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Viegas, Edna Omar, Tembe, Nelson, Nilsson, Charlotta, Meggi, Bindiya, Maueia, Cremildo, Augusto, Orvalho, Stout, Richard, Scarlatti, Gabriella, Ferrari, Guido, Earl, Patricia L., Wahren, Britta, Andersson, Sören, Robb, Merlin L., Osman, Nafissa, Biberfeld, Gunnel, Jani, Ilesh, Sandström, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913121/
https://ncbi.nlm.nih.gov/pubmed/28969431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2017.0121
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