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Refining the concept of GFAP toxicity in Alexander disease
BACKGROUND: Alexander disease is caused by dominantly acting mutations in glial fibrillary acidic protein (GFAP), the major intermediate filament of astrocytes in the central nervous system. MAIN BODY: In addition to the sequence variants that represent the origin of disease, GFAP accumulation also...
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| Publicado en: | J Neurodev Disord |
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| Autor principal: | |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6913036/ https://ncbi.nlm.nih.gov/pubmed/31838996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11689-019-9290-0 |
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