Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1

[Image: see text] YEATS-domain-containing MLLT1 is an acetyl/acyl-lysine reader domain, which is structurally distinct from well-studied bromodomains and has been strongly associated in development of cancer. Here, we characterized piperazine-urea derivatives as an acetyl/acyl-lysine mimetic moiety...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Ni, Xiaomin, Heidenreich, David, Christott, Thomas, Bennett, James, Moustakim, Moses, Brennan, Paul E., Fedorov, Oleg, Knapp, Stefan, Chaikuad, Apirat
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912866/
https://ncbi.nlm.nih.gov/pubmed/31857843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00460
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