Suppression of Angiogenesis by Targeting Cyclin-Dependent Kinase 7 in Human Umbilical Vein Endothelial Cells and Renal Cell Carcinoma: An In Vitro and In Vivo Study

Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene transcription by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor of CDK7, has antitumor effects in several human can...

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Publicado no:Cells
Main Authors: Shi, Chung-Sheng, Kuo, Kuan-Lin, Chen, Mei-Sin, Chow, Po-Ming, Liu, Shing-Hwa, Chang, Yu-Wei, Lin, Wei-Chou, Liao, Shih-Ming, Hsu, Chen-Hsun, Hsu, Fu-Shun, Chang, Hong-Chiang, Huang, Kuo-How
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912535/
https://ncbi.nlm.nih.gov/pubmed/31752390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8111469
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