The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study

After chemotherapy for the treatment of metastatic bladder urothelial carcinoma (UC), most patients inevitably encounter drug resistance and resultant treatment failure. Deubiquitinating enzymes (DUBs) remove ubiquitin from target proteins and play a critical role in maintaining protein homeostasis....

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Veröffentlicht in:Cells
Hauptverfasser: Kuo, Kuan-Lin, Liu, Shing-Hwa, Lin, Wei-Chou, Chow, Po-Ming, Chang, Yu-Wei, Yang, Shao-Ping, Shi, Chung-Sheng, Hsu, Chen-Hsun, Liao, Shih-Ming, Chang, Hong-Chiang, Huang, Kuo-How
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830310/
https://ncbi.nlm.nih.gov/pubmed/31627336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101268
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