טוען...

HA-Dependent Tropism of H5N1 and H7N9 Influenza Viruses to Human Endothelial Cells Is Determined by Reduced Stability of the HA, Which Allows the Virus To Cope with Inefficient Endosomal Acidification and Constitutively Expressed IFITM3

Previous studies revealed that certain avian influenza A viruses (IAVs), including zoonotic H5N1 and H7N9 IAVs, infect cultured human lung microvascular endothelial cells (HULEC) more efficiently than other IAVs and that tropism to HULEC is determined by viral hemagglutinin (HA). To characterize mec...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Virol
Main Authors: Hensen, Luca, Matrosovich, Tatyana, Roth, Katrin, Klenk, Hans-Dieter, Matrosovich, Mikhail
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912096/
https://ncbi.nlm.nih.gov/pubmed/31597765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01223-19
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