Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus

Mutations in the receptor-binding site of the hemagglutinin of pandemic influenza A(H1N1) 2009 viruses have been detected sporadically. An Asp222Gly (D222G) substitution has been associated with severe or fatal disease. Here we show that 222G variants infected a higher proportion of ciliated cells i...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Yan, Childs, Robert A., Matrosovich, Tatyana, Wharton, Stephen, Palma, Angelina S., Chai, Wengang, Daniels, Rodney, Gregory, Victoria, Uhlendorff, Jennifer, Kiso, Makoto, Klenk, Hans-Dieter, Hay, Alan, Feizi, Ten, Matrosovich, Mikhail
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977873/
https://ncbi.nlm.nih.gov/pubmed/20826688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01639-10
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