Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus

Mutations in the receptor-binding site of the hemagglutinin of pandemic influenza A(H1N1) 2009 viruses have been detected sporadically. An Asp222Gly (D222G) substitution has been associated with severe or fatal disease. Here we show that 222G variants infected a higher proportion of ciliated cells i...

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Bibliografiske detaljer
Main Authors: Liu, Yan, Childs, Robert A., Matrosovich, Tatyana, Wharton, Stephen, Palma, Angelina S., Chai, Wengang, Daniels, Rodney, Gregory, Victoria, Uhlendorff, Jennifer, Kiso, Makoto, Klenk, Hans-Dieter, Hay, Alan, Feizi, Ten, Matrosovich, Mikhail
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977873/
https://ncbi.nlm.nih.gov/pubmed/20826688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01639-10
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