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A Polymorphism in the Hemagglutinin of the Human Isolate of a Highly Pathogenic H5N1 Influenza Virus Determines Organ Tropism in Mice

We characterized a human H5N1 virus isolate (KAN-1) encoding a hemagglutinin (HA) with a K-to-E substitution at amino acid position 222 that was previously described to be selected in the lung of the infected patient. In mice, the growth of the HA(222E)-encoding virus was mainly confined to the lung...

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Main Authors: Mänz, Benjamin, Matrosovich, Mikhail, Bovin, Nicolai, Schwemmle, Martin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916540/
https://ncbi.nlm.nih.gov/pubmed/20519408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00850-10
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