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Extensive free-energy simulations identify water as the base in nucleotide addition by DNA polymerase
Transphosphorylation of nucleotide triphosphates is the central reaction in DNA replication by DNA polymerase as well as many other biological processes. Despite its importance, the microscopic chemical mechanism of transphosphorylation of nucleotide triphosphates is, in most cases, unknown. Here we...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6911213/ https://ncbi.nlm.nih.gov/pubmed/31757846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914613116 |
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