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Extensive free-energy simulations identify water as the base in nucleotide addition by DNA polymerase
Transphosphorylation of nucleotide triphosphates is the central reaction in DNA replication by DNA polymerase as well as many other biological processes. Despite its importance, the microscopic chemical mechanism of transphosphorylation of nucleotide triphosphates is, in most cases, unknown. Here we...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6911213/ https://ncbi.nlm.nih.gov/pubmed/31757846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914613116 |
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