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Extensive free-energy simulations identify water as the base in nucleotide addition by DNA polymerase
Transphosphorylation of nucleotide triphosphates is the central reaction in DNA replication by DNA polymerase as well as many other biological processes. Despite its importance, the microscopic chemical mechanism of transphosphorylation of nucleotide triphosphates is, in most cases, unknown. Here we...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6911213/ https://ncbi.nlm.nih.gov/pubmed/31757846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914613116 |
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