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High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension
Sickle cell disease (SCD) is caused by a variant hemoglobin molecule that polymerizes inside red blood cells (RBCs) in reduced oxygen tension. Treatment development has been slow for this typically severe disease, but there is current optimism for curative gene transfer strategies to induce expressi...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6911208/ https://ncbi.nlm.nih.gov/pubmed/31767751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914056116 |
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