Bottleneck and selection in the germline and maternal age influence transmission of mitochondrial DNA in human pedigrees

Heteroplasmy—the presence of multiple mitochondrial DNA (mtDNA) haplotypes in an individual—can lead to numerous mitochondrial diseases. The presentation of such diseases depends on the frequency of the heteroplasmic variant in tissues, which, in turn, depends on the dynamics of mtDNA transmissions...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Zaidi, Arslan A., Wilton, Peter R., Su, Marcia Shu-Wei, Paul, Ian M., Arbeithuber, Barbara, Anthony, Kate, Nekrutenko, Anton, Nielsen, Rasmus, Makova, Kateryna D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911200/
https://ncbi.nlm.nih.gov/pubmed/31757848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906331116
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