FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops

Cancer cells maintain their telomeres by either re-activating telomerase or adopting the homologous recombination (HR)-based Alternative Lengthening of Telomere (ALT) pathway. Among the many prominent features of ALT cells, C-circles (CC) formation is considered to be the most specific and quantifia...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pan, Xiaolei, Chen, Yun, Biju, Beena, Ahmed, Naveed, Kong, Joyce, Goldenberg, Marti, Huang, Judy, Mohan, Nandakumar, Klosek, Stephanie, Parsa, Kian, Guh, Chia-Yu, Lu, Robert, Pickett, Hilda A., Chu, Hsueh-Ping, Zhang, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911001/
https://ncbi.nlm.nih.gov/pubmed/31836759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55537-5
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