Perturbations of Ubiquitin-Proteasome-Mediated Proteolysis in Aging and Alzheimer’s Disease

The ubiquitin-proteasome pathway (UPP) has multiple roles in the normal nervous system, including the development of synaptic connections and synaptic plasticity. Research over the past several years has indicated a role for the UPP in aging without any overt pathology in the brain. In addition, mal...

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Опубликовано в: :Front Aging Neurosci
Главные авторы: Hegde, Ashok N., Smith, Spencer G., Duke, Lindsey M., Pourquoi, Allison, Vaz, Savannah
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2019
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910070/
https://ncbi.nlm.nih.gov/pubmed/31866849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00324
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