EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease

BACKGROUND: EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. These processes are pivotal in the pathophysiology of Alzheimer’s disease (AD), characterized by synapse dysfunction and loss, and the progressive loss of memory and other cognitive function...

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Dettagli Bibliografici
Pubblicato in:Alzheimers Res Ther
Autori principali: Poppe, Lindsay, Rué, Laura, Timmers, Mieke, Lenaerts, Annette, Storm, Annet, Callaerts-Vegh, Zsuzsanna, Courtand, Gilles, de Boer, Antina, Smolders, Silke, Van Damme, Philip, Van Den Bosch, Ludo, D’Hooge, Rudi, De Strooper, Bart, Robberecht, Wim, Lemmens, Robin
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6909519/
https://ncbi.nlm.nih.gov/pubmed/31831046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0554-4
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