Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy

EphA4 is a receptor of the Eph-ephrin system, which plays an important role in axon guidance during development. Previously, we identified EphA4 as a genetic modifier of amyotrophic lateral sclerosis (ALS) in both zebrafish and rodent models, via modulation of the intrinsic vulnerability, and re-spr...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Poppe, Lindsay, Smolders, Silke, Rué, Laura, Timmers, Mieke, Lenaerts, Annette, Storm, Annet, Schoonaert, Lies, de Boer, Antina, Van Damme, Philip, Van Den Bosch, Ludo, Robberecht, Wim, Lemmens, Robin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877733/
https://ncbi.nlm.nih.gov/pubmed/31803009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.01233
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