EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease

BACKGROUND: EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. These processes are pivotal in the pathophysiology of Alzheimer’s disease (AD), characterized by synapse dysfunction and loss, and the progressive loss of memory and other cognitive function...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Poppe, Lindsay, Rué, Laura, Timmers, Mieke, Lenaerts, Annette, Storm, Annet, Callaerts-Vegh, Zsuzsanna, Courtand, Gilles, de Boer, Antina, Smolders, Silke, Van Damme, Philip, Van Den Bosch, Ludo, D’Hooge, Rudi, De Strooper, Bart, Robberecht, Wim, Lemmens, Robin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6909519/
https://ncbi.nlm.nih.gov/pubmed/31831046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0554-4
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