Adaption of human antibody λ and κ light chain architectures to CDR repertoires

Monoclonal antibodies bind with high specificity to a wide range of diverse antigens, primarily mediated by their hypervariable complementarity determining regions (CDRs). The defined antigen binding loops are supported by the structurally conserved β-sandwich framework of the light chain (LC) and h...

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Udgivet i:Protein Eng Des Sel
Main Authors: van der Kant, Rob, Bauer, Joschka, Karow-Zwick, Anne R, Kube, Sebastian, Garidel, Patrick, Blech, Michaela, Rousseau, Frederic, Schymkowitz, Joost
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908821/
https://ncbi.nlm.nih.gov/pubmed/31535139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzz012
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