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Adaption of human antibody λ and κ light chain architectures to CDR repertoires
Monoclonal antibodies bind with high specificity to a wide range of diverse antigens, primarily mediated by their hypervariable complementarity determining regions (CDRs). The defined antigen binding loops are supported by the structurally conserved β-sandwich framework of the light chain (LC) and h...
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| Veröffentlicht in: | Protein Eng Des Sel |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6908821/ https://ncbi.nlm.nih.gov/pubmed/31535139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzz012 |
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