Prediction and Reduction of the Aggregation of Monoclonal Antibodies

Protein aggregation remains a major area of focus in the production of monoclonal antibodies. Improving the intrinsic properties of antibodies can improve manufacturability, attrition rates, safety, formulation, titers, immunogenicity, and solubility. Here, we explore the potential of predicting and...

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Bibliografiska uppgifter
I publikationen:J Mol Biol
Huvudupphovsmän: van der Kant, Rob, Karow-Zwick, Anne R., Van Durme, Joost, Blech, Michaela, Gallardo, Rodrigo, Seeliger, Daniel, Aßfalg, Kerstin, Baatsen, Pieter, Compernolle, Griet, Gils, Ann, Studts, Joey M., Schulz, Patrick, Garidel, Patrick, Schymkowitz, Joost, Rousseau, Frederic
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397608/
https://ncbi.nlm.nih.gov/pubmed/28322916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.03.014
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