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Prediction and Reduction of the Aggregation of Monoclonal Antibodies
Protein aggregation remains a major area of focus in the production of monoclonal antibodies. Improving the intrinsic properties of antibodies can improve manufacturability, attrition rates, safety, formulation, titers, immunogenicity, and solubility. Here, we explore the potential of predicting and...
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| Veröffentlicht in: | J Mol Biol |
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| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5397608/ https://ncbi.nlm.nih.gov/pubmed/28322916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.03.014 |
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