Prediction and Reduction of the Aggregation of Monoclonal Antibodies

Protein aggregation remains a major area of focus in the production of monoclonal antibodies. Improving the intrinsic properties of antibodies can improve manufacturability, attrition rates, safety, formulation, titers, immunogenicity, and solubility. Here, we explore the potential of predicting and...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: van der Kant, Rob, Karow-Zwick, Anne R., Van Durme, Joost, Blech, Michaela, Gallardo, Rodrigo, Seeliger, Daniel, Aßfalg, Kerstin, Baatsen, Pieter, Compernolle, Griet, Gils, Ann, Studts, Joey M., Schulz, Patrick, Garidel, Patrick, Schymkowitz, Joost, Rousseau, Frederic
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397608/
https://ncbi.nlm.nih.gov/pubmed/28322916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.03.014
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