Preparation of hybrid porcine thymus containing non-human primate thymic epithelial cells in miniature swine

BACKGROUND: We have achieved greater than a 6-month survival of a life-supporting kidney co-transplanted with a vascularized thymic graft into non-human primates (NHP). Although we have achieved pig-specific unresponsiveness in vitro, immunosuppression was not able to be fully weaned. Studies in mic...

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Veröffentlicht in:Xenotransplantation
Hauptverfasser: Sekijima, Mitsuhiro, Sahara, Hisashi, Shimizu, Akira, Iwanaga, Takehiro, Murokawa, Takahiro, Ariyoshi, Yuichi, Pomposelli, Thomas, Maharlooei, Mohsen Khosravi, Sykes, Megan, Yamada, Kazuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908759/
https://ncbi.nlm.nih.gov/pubmed/31293016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12543
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