A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice

Aberrant autophagy is a major risk factor for inflammatory diseases and cancer. However, the genetic basis and underlying mechanisms are less established. UVRAG is a tumor suppressor candidate involved in autophagy, which is truncated in cancers by a frameshift (FS) mutation and expressed as a short...

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Vydáno v:Nat Commun
Hlavní autoři: Quach, Christine, Song, Ying, Guo, Hongrui, Li, Shun, Maazi, Hadi, Fung, Marshall, Sands, Nathaniel, O’Connell, Douglas, Restrepo-Vassalli, Sara, Chai, Billy, Nemecio, Dali, Punj, Vasu, Akbari, Omid, Idos, Gregory E., Mumenthaler, Shannon M., Wu, Nancy, Martin, Sue Ellen, Hagiya, Ashley, Hicks, James, Cui, Hengmin, Liang, Chengyu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908726/
https://ncbi.nlm.nih.gov/pubmed/31831743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13475-w
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