Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

Autophagy-related factors are implicated in metabolic adaptation and cancer metastasis. However, the role of autophagy factors in cancer progression and their effect in treatment response remain largely elusive. Recent studies have shown that UVRAG, a key autophagic tumour suppressor, is mutated in...

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Vydáno v:Nat Commun
Hlavní autoři: He, Shanshan, Zhao, Zhen, Yang, Yongfei, O'Connell, Douglas, Zhang, Xiaowei, Oh, Soohwan, Ma, Binyun, Lee, Joo-Hyung, Zhang, Tian, Varghese, Bino, Yip, Janae, Dolatshahi Pirooz, Sara, Li, Ming, Zhang, Yong, Li, Guo-Min, Ellen Martin, Sue, Machida, Keigo, Liang, Chengyu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526116/
https://ncbi.nlm.nih.gov/pubmed/26234763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8839
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