Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

Autophagy-related factors are implicated in metabolic adaptation and cancer metastasis. However, the role of autophagy factors in cancer progression and their effect in treatment response remain largely elusive. Recent studies have shown that UVRAG, a key autophagic tumour suppressor, is mutated in...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: He, Shanshan, Zhao, Zhen, Yang, Yongfei, O'Connell, Douglas, Zhang, Xiaowei, Oh, Soohwan, Ma, Binyun, Lee, Joo-Hyung, Zhang, Tian, Varghese, Bino, Yip, Janae, Dolatshahi Pirooz, Sara, Li, Ming, Zhang, Yong, Li, Guo-Min, Ellen Martin, Sue, Machida, Keigo, Liang, Chengyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526116/
https://ncbi.nlm.nih.gov/pubmed/26234763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8839
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