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A model of DNA damage response activation at stalled replication forks by SPRTN

The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.

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Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Bruhn, Christopher, Foiani, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908633/
https://ncbi.nlm.nih.gov/pubmed/31831745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13610-7
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