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Disruption of palmitate-mediated localization; a shared pathway of force and anesthetic activation of TREK-1 channels.
TWIK related K+ channel (TREK-1) is a mechano- and anesthetic sensitive channel that when activated attenuates pain and causes anesthesia. Recently the enzyme phospholipase D2 (PLD2) was shown to bind to the channel and generate a local high concentration of phosphatidic acid (PA), an anionic signal...
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| Publicado en: | Biochim Biophys Acta Biomembr |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6907892/ https://ncbi.nlm.nih.gov/pubmed/31672538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2019.183091 |
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