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Studies on the mechanism of general anesthesia

Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules that robustly activate TWIK-related K(+) channels (TREK-1) and reversibly induce loss of consciousness. For 100 y, anesthetics were speculated to target cellular membranes, yet no plausible mechanism emerged to explain...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Pavel, Mahmud Arif, Petersen, E. Nicholas, Wang, Hao, Lerner, Richard A., Hansen, Scott B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306821/
https://ncbi.nlm.nih.gov/pubmed/32467161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004259117
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