Phosphorylation of Syntaxin 17 by TBK1 controls autophagy initiation

Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here we report that Stx17 functions in assembly of protein complexes during autophagy initiation. Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls formation of the ATG13(+)FIP200(+) mammalian pre-autophagosomal s...

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Gepubliceerd in:Dev Cell
Hoofdauteurs: Kumar, Suresh, Gu, Yuexi, Abudu, Yakubu Princely, Bruun, Jack-Ansgar, Jain, Ashish, Farzam, Farzin, Mudd, Michal, Anonsen, Jan Haug, Rusten, Tor Erik, Kasof, Gary, Ktistakis, Nicholas, Lidke, Keith A., Johansen, Terje, Deretic, Vojo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907693/
https://ncbi.nlm.nih.gov/pubmed/30827897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.01.027
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