A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping

Limb-girdle muscular dystrophy type 2C is caused by autosomal recessive mutations in the γ-sarcoglycan (SGCG) gene. The most common SGCG mutation is a single nucleotide deletion from a stretch of five thymine residues in SGCG exon 6 (521ΔT). This founder mutation disrupts the transcript reading fram...

Full description

Saved in:
Bibliographic Details
Published in:Dis Model Mech
Main Authors: Demonbreun, Alexis R., Wyatt, Eugene J., Fallon, Katherine S., Oosterbaan, Claire C., Page, Patrick G., Hadhazy, Michele, Quattrocelli, Mattia, Barefield, David Y., McNally, Elizabeth M.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906631/
https://ncbi.nlm.nih.gov/pubmed/31582396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.040832
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items