A causal role for TRESK loss of function in migraine mechanisms

The two-pore potassium channel, TRESK has been implicated in nociception and pain disorders. We have for the first time investigated TRESK function in human nociceptive neurons using induced pluripotent stem cell-based models. Nociceptors from migraine patients with the F139WfsX2 mutation show loss...

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Dettagli Bibliografici
Pubblicato in:Brain
Autori principali: Pettingill, Philippa, Weir, Greg A, Wei, Tina, Wu, Yukyee, Flower, Grace, Lalic, Tatjana, Handel, Adam, Duggal, Galbha, Chintawar, Satyan, Cheung, Jonathan, Arunasalam, Kanisa, Couper, Elizabeth, Haupt, Larisa M, Griffiths, Lyn R, Bassett, Andrew, Cowley, Sally A, Cader, M Zameel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906598/
https://ncbi.nlm.nih.gov/pubmed/31742594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz342
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