A causal role for TRESK loss of function in migraine mechanisms

The two-pore potassium channel, TRESK has been implicated in nociception and pain disorders. We have for the first time investigated TRESK function in human nociceptive neurons using induced pluripotent stem cell-based models. Nociceptors from migraine patients with the F139WfsX2 mutation show loss...

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Библиографические подробности
Опубликовано в: :Brain
Главные авторы: Pettingill, Philippa, Weir, Greg A, Wei, Tina, Wu, Yukyee, Flower, Grace, Lalic, Tatjana, Handel, Adam, Duggal, Galbha, Chintawar, Satyan, Cheung, Jonathan, Arunasalam, Kanisa, Couper, Elizabeth, Haupt, Larisa M, Griffiths, Lyn R, Bassett, Andrew, Cowley, Sally A, Cader, M Zameel
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906598/
https://ncbi.nlm.nih.gov/pubmed/31742594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz342
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