Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis

Tissue-nonspecific alkaline phosphatase (TNAP) is a ubiquitous enzyme present in many cells and tissues, including the central nervous system. Yet its functions at the brain-immune axis remain unclear. The goal of this study was to use a novel small molecular inhibitor of TNAP, SBI-425, to interroga...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Brichacek, Allison L., Benkovic, Stanley A., Chakraborty, Sreeparna, Nwafor, Divine C., Wang, Wei, Jun, Sujung, Dakhlallah, Duaa, Geldenhuys, Werner J., Pinkerton, Anthony B., Millán, José Luis, Brown, Candice M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906465/
https://ncbi.nlm.nih.gov/pubmed/31827139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55154-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items