Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis

Tissue-nonspecific alkaline phosphatase (TNAP) is a ubiquitous enzyme present in many cells and tissues, including the central nervous system. Yet its functions at the brain-immune axis remain unclear. The goal of this study was to use a novel small molecular inhibitor of TNAP, SBI-425, to interroga...

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Udgivet i:Sci Rep
Main Authors: Brichacek, Allison L., Benkovic, Stanley A., Chakraborty, Sreeparna, Nwafor, Divine C., Wang, Wei, Jun, Sujung, Dakhlallah, Duaa, Geldenhuys, Werner J., Pinkerton, Anthony B., Millán, José Luis, Brown, Candice M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906465/
https://ncbi.nlm.nih.gov/pubmed/31827139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55154-2
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