Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is associated with increased risks of hematological malignancies. While TP53 mutations have been identified in CHIP, the molecular mechanisms by which mutant p53 promotes hematopoietic stem and progenitor cell (HSPC) expan...

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Опубликовано в: :Nat Commun
Главные авторы: Chen, Sisi, Wang, Qiang, Yu, Hao, Capitano, Maegan L., Vemula, Sasidhar, Nabinger, Sarah C., Gao, Rui, Yao, Chonghua, Kobayashi, Michihiro, Geng, Zhuangzhuang, Fahey, Aidan, Henley, Danielle, Liu, Stephen Z., Barajas, Sergio, Cai, Wenjie, Wolf, Eric R., Ramdas, Baskar, Cai, Zhigang, Gao, Hongyu, Luo, Na, Sun, Yang, Wong, Terrence N., Link, Daniel C., Liu, Yunlong, Boswell, H. Scott, Mayo, Lindsey D., Huang, Gang, Kapur, Reuben, Yoder, Mervin C., Broxmeyer, Hal E., Gao, Zhonghua, Liu, Yan
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906427/
https://ncbi.nlm.nih.gov/pubmed/31827082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13542-2
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